Preparation and pharmacokinetics evaluation of oral self-emulsifying system for poorly water-soluble drug Lornoxicam
نویسندگان
چکیده
منابع مشابه
Development of supersaturatable self-emulsifying drug delivery system formulations for improving the oral absorption of poorly soluble drugs.
The supersaturatable self-emulsifying drug delivery system (S-SEDDS) represents a new thermodynamically stable formulation approach wherein it is designed to contain a reduced amount of a surfactant and a water-soluble cellulosic polymer (or other polymers) to prevent precipitation of the drug by generating and maintaining a supersaturated state in vivo. The S-SEDDS formulations can result in e...
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BACKGROUND Indirubin, isolated from the leaves of the Chinese herb Isatis tinctoria L, is a protein kinase inhibitor and promising antitumor agent. However, the poor water solubility of indirubin has limited its application. In this study, a supersaturatable self-microemulsifying drug delivery system (S-SMEDDS) was developed to improve the oral bioavailability of indirubin. METHODS A prototyp...
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The present study deals with formulation of a valsartan based Self emulsifying drug delivery system of a poorly water soluble drug. SEDDS are the isotropic mixtures of oil, surfactant, co surfactant and drug that form oil in water microemulsion when introduced into aqueous phase under gentle agitation. The present research work describes a Self Emulsifying Drug Delivery System (SEDDS) of valsar...
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متن کاملDesign, Development and In Vitro Characterization of Self Emulsifying Drug Delivery System for Irbesartan
The objectives of present investigations were to optimize concentration of oil, surfactant and cosurfactant by pseudoternary phase diagrams and to develop a stable formulation of self emulsifying drug delivery system (SEDDS) in order to enhance the dissolution rate of poorly soluble Irbesartan (IBS) by SEDDS. Pseudoternary phase diagrams were constructed to identify the self emulsifying region....
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ژورنال
عنوان ژورنال: Drug Delivery
سال: 2014
ISSN: 1071-7544,1521-0464
DOI: 10.3109/10717544.2014.885615